We have prepared a list of Tamil Nadu holidays 2021. The list includes all regional, public, and bank holidays in Tamil Nadu in 2021. You can refer to the Tamil Nadu Holiday List 2021 and plan your leaves accordingly.
| Date | Day | Holiday |
| Jan 1 | Friday | New Year's Day |
| Jan 14 | Thursday | Pongal |
| Jan 15 | Friday | Thiruvalluvar Day |
| Jan 16 | Saturday | Uzhavar Thirunal |
| Jan 26 | Tuesday | Republic Day |
| Apr 1 | Thursday | Annual closing of bank accounts |
| Apr 2 | Friday | Good Friday |
| Apr 13 | Tuesday | Telugu New Year's Day |
| Apr 14 | Wednesday | Tamil New year's Day and Dr. B.R. Ambedkar's Birthday |
| Apr 25 | Sunday | Mahavir Jayanthi |
| May 1 | Saturday | May Day |
| May 14 | Friday | Ramzan (idu'l Fitr) |
| Jul 21 | Wednesday | Bakrid (Idul Azha) |
| Aug 15 | Sunday | Independence Day |
| Aug 20 | Friday | Muharram |
| Aug 30 | Monday | Krishna Jayanthi |
| Sep 10 | Friday | Vinayakar Chathurthi |
| Oct 2 | Saturday | Ganthi Jayanthi |
| Oct 14 | Thursday | Ayutha Pooja |
| Oct 15 | Friday | Vijaya Dasami |
| Oct 19 | Tuesday | Milad-un-Nabi |
| Nov 4 | Thursday | Deepavali |
| Dec 25 | Saturday | Christmas |